Search results for "density [charge]"
showing 8 items of 318 documents
Proposal for a preventive protocol for medication-related osteonecrosis of the jaw.
2021
Background Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse reaction experienced by some patients exposed to certain drugs (antiresorptives such as bisphosphonates or denosumab, and antiangiogenic drugs). From a review of the literature it appears that there is no uniform criterion when selecting preventive measures; these vary according to author. Likewise, the measures recommended are usually general, so that in few cases they result in specific actions to be applied depending on the different variables involved such as the type of drug used, the duration of its application, the underlying pathology, the presence or absence of risk factors, etc. The aim of this stud…
Dexrazoxane shows cytoprotective effects in zoledronic acid-treated human cells in vitro and in the rabbit tibia model in vivo
2012
Abstract Introduction Bisphosphonates are important and effective drugs in oncology and osteoporosis therapy. They accumulate in the bone matrix becoming released and active by bone resorption. This leads to effective inhibition of tumor cells and bone degradation. A side effect of bisphosphonates similar to other drugs like denosumab is osteonecrosis of the jaws (ONJ). This problem mostly occurs after tooth extraction. We studied the cytoprotectant dexrazoxane known from anthracycline chemotherapy for cytoprotection in nitrogen-containing bisphosphonate treated cells and in the rabbit tibia model to evaluate a possible value in ONJ management. Materials & methods Human osteoblasts (HOB) P2…
Silicate modulates the cross-talk between osteoblasts (SaOS-2) and osteoclasts (RAW 264.7 cells): inhibition of osteoclast growth and differentiation
2012
It has been shown that inorganic monomeric and polymeric silica/silicate, in the presence of the biomineralization cocktail, increases the expression of osteoprotegerin (OPG) in osteogenic SaOS-2 sarcoma cells in vitro. In contrast, silicate does not affect the steady-state gene expression level of the osteoclastogenic ligand receptor activator of NF-κB ligand (RANKL). In turn it can be expected that the concentration ratio of the mediators OPG/RANKL increases in the presence of silicate. In addition, silicate enhances the growth potential of SaOS-2 cells in vitro, while it causes no effect on RAW 264.7 cells within a concentration range of 10-100 µM. Applying a co-cultivation assay system,…
Successful treatment of primary chronic osteomyelitis in SAPHO syndrome with bisphosphonates.
2008
Summary The treatment of the painful osteomyelitis in patients with SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) is often a problem. A 53-year-old woman had experienced palmo-plantar pustular skin lesions for four years, and in the past two years complained about progressive breath-and movement-dependent pain of the sternum. On examination she had extensive palmoplantar pustules and a painful swelling in the area of the right sternoclavicular joint. The three-phase bone scintigraphy showed a strong focal enrichment in the right sternoclavicular joint and at the transition from the manubrium to the corpus sterni suggesting active osteo-chondritis. Initially prednisolo…
The Hajłasz Capacity Density Condition is Self-improving
2022
We prove a self-improvement property of a capacity density condition for a nonlocal Hajlasz gradient in complete geodesic spaces with a doubling measure. The proof relates the capacity density condition with boundary Poincare inequalities, adapts Keith-Zhong techniques for establishing local Hardy inequalities and applies Koskela-Zhong arguments for proving self-improvement properties of local Hardy inequalities. This leads to a characterization of the Hajlasz capacity density condition in terms of a strict upper bound on the upper Assouad codimension of the underlying set, which shows the self-improvement property of the Hajlasz capacity density condition. Open Access funding provided than…
Investigating the Structure of Vela X
2018
Vela X is the prototypical example of a pulsar wind nebula whose morphology and detailed structure have been affected by the interaction with the reverse shock of its host supernova remnant. The resulting complex of filamentary structure and mixed-in ejecta embedded in a nebula that is offset from the pulsar provides the best example we have of this middle-age state that characterizes a significant fraction of composite SNRs, and perhaps all of the large-diameter PWNe seen as TeV sources. Here we report on an XMM-Newton Large Project study of Vela X, supplemented by additional Chandra observations. Through broad spectral modeling as well as detailed spectral investigations of discrete emiss…
A microsimulation calibration methodology based on speed-density relationships for freeways
2014
This paper describes the calibration methodology based on speed-density relationships in the microsimulation calibration process, stated that they represent the traffic flow phenomenon in a wide range of operational conditions and well summarize all the information that may be collected on field (or following a run of the microsimulation model) on two of the three key variables of traffic flow. The matching of speed-density relationships from field and simulation was evaluated using statistical analysis as technique of pattern recognition. A test freeway segment under uncongested traffic conditions was selected as case study; based on traffic data observed at A22 Brenner Freeway, Italy, sta…
Strictly correlated electrons approach to excitation energies of dissociating molecules
2019
In this work we consider a numerically solvable model of a two-electron diatomic molecule to study a recently proposed approximation based on the density functional theory of so-called strictly correlated electrons (SCE). We map out the full two-particle wave function for a wide range of bond distances and interaction strengths and obtain analytic results for the two-particle states and eigenenergies in various limits of strong and weak interactions, and in the limit of large bond distance. We then study the so-called Hartree-exchange-correlation (Hxc) kernel of time-dependent density functional theory which is a key ingredient in calculating excitation energies. We study an approximation b…